Photobioregulation (PBM) describes the use of red or near-infrared light to stimulate, heal, regenerate, and protect injured,
degrading or at risk of death tissues.
The brain is one of the most important organ systems in life, and its function is usually one that humans worry about.
The brain suffers from many different diseases, which can be divided into three broad categories: traumatic events (stroke,
traumatic brain injury and global ischemia), degenerative diseases (dementia, Alzheimer's disease and Parkinson's disease) and
psychotic disorders (depression, anxiety, post-traumatic stress disorders).
There is evidence that all these seemingly different conditions can be usefully affected by shining light into the head.
It may even be possible to use PBM for cognitive enhancement in normally healthy people.
Pbm Brain Red Light Therapy Helmet Medical Bioregulation Helmet For Depression Relief Mental Health Treatment
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Brain PBM therapy
1. Red/NIR light is able to stimulate complex IV of the mitochondrial respiratory chain (cytochrome c oxidase) and increase ATPsynthesis.
2. Moreover, light absorption by ion channels results in release of Ca2+ and leads to activation of transcription factors and
gene expression.
3. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and
antioxidant responses, as well as neurogenesis and synaptogenesis.
4. Its therapeutic role in disorders such as dementia and Parkinson’s disease, as well as to treat stroke, brain
trauma, and depression has gained increasing interest.
In the transcranial PBM approach, delivering a sufficient dose to achieve optimal stimulation is challenging due to exponential attenuation of light penetration in tissue. Alternative approaches such as intracranial and intranasal light delivery methods have been suggested to overcome this limitation.
gene expression.
3. Brain PBM therapy enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and
antioxidant responses, as well as neurogenesis and synaptogenesis.
4. Its therapeutic role in disorders such as dementia and Parkinson’s disease, as well as to treat stroke, brain
trauma, and depression has gained increasing interest.
In the transcranial PBM approach, delivering a sufficient dose to achieve optimal stimulation is challenging due to exponential attenuation of light penetration in tissue. Alternative approaches such as intracranial and intranasal light delivery methods have been suggested to overcome this limitation.
Photobiomodulation underlying mechanisms at the cellular and molecular levels
Light at 600–850 nm is absorbed by the mitochondrial electron transfer chain and leads to upregulation of the neuronal respiratory
capacity. The near-infrared light at range of 900–1100 nm is absorbed by structured water clusters formed in or on a
heat/light-gated ion channels. An increase in vibrational energy of water cluster leads to perturb the protein structure and
opening the channel which ultimately allows modulation of intracellular Ca2+ levels. The absorption of green light by neuronal
opsin photoreceptors (OPN2–5) activates transient receptor potential channels which causes non-selective permeabilization to Ca2+,
Na+ and Mg2+. The cryptochromes (a class of flavoprotein blue-light signaling receptors) absorb blue light and seems to activate
the transducing cellular signals via part of the optic nerve to the suprachiasmatic nucleus in the brain, which is important in
regulation of the circadian clock.
capacity. The near-infrared light at range of 900–1100 nm is absorbed by structured water clusters formed in or on a
heat/light-gated ion channels. An increase in vibrational energy of water cluster leads to perturb the protein structure and
opening the channel which ultimately allows modulation of intracellular Ca2+ levels. The absorption of green light by neuronal
opsin photoreceptors (OPN2–5) activates transient receptor potential channels which causes non-selective permeabilization to Ca2+,
Na+ and Mg2+. The cryptochromes (a class of flavoprotein blue-light signaling receptors) absorb blue light and seems to activate
the transducing cellular signals via part of the optic nerve to the suprachiasmatic nucleus in the brain, which is important in
regulation of the circadian clock.
Mechanism of photobiomodulation therapy in mitochondria
(A) The flow of electrons and protons through the mitochondrial respiratory chain. Photobiomodulation stimulates cytochrome c
oxidase, improves its catalytic activity, and elevates ATP synthesis. All these results in enhancement of neuronal respiration and
metabolic capacity. (B) The structure of cytochrome c oxidase and electrons path through its subunits. The complex contains two
copper centers as well as two heme prosthetic groups. Photobiomodulation may dissociate nitric oxide from binuclear center
(a3/CuB), allowing oxygen to return, and facilitates electron transfer and increases proton gradient.
oxidase, improves its catalytic activity, and elevates ATP synthesis. All these results in enhancement of neuronal respiration and
metabolic capacity. (B) The structure of cytochrome c oxidase and electrons path through its subunits. The complex contains two
copper centers as well as two heme prosthetic groups. Photobiomodulation may dissociate nitric oxide from binuclear center
(a3/CuB), allowing oxygen to return, and facilitates electron transfer and increases proton gradient.
Brain tissue-specific functional processes that occur after brain photobiomodulation therapy
On a cellular level, photobiomodulation can reduce apoptosis and excitoxicity, increase antioxidants, neurotrophins and stimulate
neuroprogenitor cells. On a tissue level, photobiomodulation therapy can increase blood flow and angiogenesis, reduce inflammation
and help neurons form new connections.
BDNF, brain-derived neurotrophic factor;
GDNF, glial-derived neurotrophic factor; NGF, nerve growth factor;
SOD, superoxide dismutase.
neuroprogenitor cells. On a tissue level, photobiomodulation therapy can increase blood flow and angiogenesis, reduce inflammation
and help neurons form new connections.
BDNF, brain-derived neurotrophic factor;
GDNF, glial-derived neurotrophic factor; NGF, nerve growth factor;
SOD, superoxide dismutase.
Feature
* NIR light can penetrate the head and reach the brain.
* NIR is absorbed by cytochrome c oxidase in mitochondria.
* Heat-gated ion channels also play a role.
* Increased blood flow, energy, neuroprotection, less inflammation, brain repair.
* Can treat traumatic (stroke, TBI), neurodegenerative and psychiatric diseases
* NIR is absorbed by cytochrome c oxidase in mitochondria.
* Heat-gated ion channels also play a role.
* Increased blood flow, energy, neuroprotection, less inflammation, brain repair.
* Can treat traumatic (stroke, TBI), neurodegenerative and psychiatric diseases
Indications
1. Traumatic events (stroke, traumatic brain injury, and global ischemia).
2. Degenerative diseases (dementia, Alzheimer's and Parkinson's).
3. Psychiatric disorders (depression, anxiety, post traumatic stress disorder).
Contraindication
1. Avoid direct exposure to the eyes, pregnant women's abdomen, melanoma, brown spots.
2. Taboo patients with early and middle stage malignant tumors.
3. Contraindications to patients with acute bleeding disorders.
1. Traumatic events (stroke, traumatic brain injury, and global ischemia).
2. Degenerative diseases (dementia, Alzheimer's and Parkinson's).
3. Psychiatric disorders (depression, anxiety, post traumatic stress disorder).
Contraindication
1. Avoid direct exposure to the eyes, pregnant women's abdomen, melanoma, brown spots.
2. Taboo patients with early and middle stage malignant tumors.
3. Contraindications to patients with acute bleeding disorders.
Specification
Name | Brain Photobiomodulation Machine |
Place of Origin | China |
Guangdong | |
Brand Name | SSCH/Suyzeko |
Model Number | Helmet |
Instrument classification | Class II |
Warranty | 1 Year |
After-sale Service | Return and Replacement |
Product name | brain photobiomodulation 810nm helmet |
Function 1 | Treat Ischemic stroke, Traumatic brain injury, |
Function 2 | Alzheimer's disease, Parkinson's disease |
LED quantity | 256pcs |
Wavelength | 810 nm |
Color | White |
Power 1 | 60 mW per LED, total 15 W |
Power 2 | 24 mW/cm2 |
Certificate | CE |
OEM | Supported |
Company Profile
Shenzhen Guangyang Zhongkang Technology Co., Ltd. was established in 2013. It is a fast-growing enterprise laser therapy device supplier integrating production and sales of health laser therapy devices. After 8 years of hard work and development, we have now become a leading company in China. One of the manufacturers and suppliers of laser treatment equipment, we have always maintained good relationships with many nutritional product factories, medical care research institutions and hospitals in China, and enjoy a high reputation in the domestic and foreign medical care and rehabilitation markets. Our factory focuses on laser treatment machines, such as laser treatment watches, knee massagers, laser pain relief devices, etc. We support OEM and ODM services. Our medical products have CE, FC and medical device certificates. We also produce phototherapy bed, Metatron Hunter 4025 NLS. 8D NLS, quantum analyzer, bioresonance therapy machine and skin analyzer. We provide more than 200 OEM products, which are exported to about 40 countries and regions all over the world. In order to provide customers with more professional services, we established a new sales and marketing center in Shenzhen Guanlan Innovation Silicon Valley Industrial Park in 2019.
FAQ
1. who are we?
We are based in Guangdong, China, start from 2013,sell to North America(30.00%),Northern Europe(20.00%),Eastern Europe(15.00%),Domestic Market(10.00%),Western Europe(7.00%),Central America(5.00%),Southern Europe(3.00%),South America(3.00%),Mid East(2.00%),Africa(2.00%),Southeast Asia(1.00%),Eastern Asia(1.00%),Oceania(1.00%). There are total about 11-50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Laser treatment helmet,Laser treatment watch,Infrared phototherapy pad,Led Red Light Therapy Bed,Medical Professionals Light Therapy Pad
4. why should you buy from us not from other suppliers?
We were established in 2013 as a fast-growing enterprise laser therapy device supplier integrating production and sales of health laser therapy devices, one of China's leading laser therapy device manufacturers and suppliers, providing more than 200 OEM pr
5. what services can we provide?
Accepted Delivery Terms: FOB；
Accepted Payment Currency:USD,EUR,HKD,CNY;
Accepted Payment Type: T/T,L/C,Credit Card,PayPal;
Language Spoken:English,Chinese
We are based in Guangdong, China, start from 2013,sell to North America(30.00%),Northern Europe(20.00%),Eastern Europe(15.00%),Domestic Market(10.00%),Western Europe(7.00%),Central America(5.00%),Southern Europe(3.00%),South America(3.00%),Mid East(2.00%),Africa(2.00%),Southeast Asia(1.00%),Eastern Asia(1.00%),Oceania(1.00%). There are total about 11-50 people in our office.
2. how can we guarantee quality?
Always a pre-production sample before mass production;
Always final Inspection before shipment;
3.what can you buy from us?
Laser treatment helmet,Laser treatment watch,Infrared phototherapy pad,Led Red Light Therapy Bed,Medical Professionals Light Therapy Pad
4. why should you buy from us not from other suppliers?
We were established in 2013 as a fast-growing enterprise laser therapy device supplier integrating production and sales of health laser therapy devices, one of China's leading laser therapy device manufacturers and suppliers, providing more than 200 OEM pr
5. what services can we provide?
Accepted Delivery Terms: FOB；
Accepted Payment Currency:USD,EUR,HKD,CNY;
Accepted Payment Type: T/T,L/C,Credit Card,PayPal;
Language Spoken:English,Chinese
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